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Glioblastoma (GBM). GBM is the most Arkansas Razorbacks NCAA White Crocs and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.
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Rugby is a lot more fluid. There is a squad of around 50 in a fully pro club, but only 23 in a match day squad. About 30 players at a club are regular performers in the “first team” squad, whilst the other 20 are developing players or reserves who step in as injury cover. The second tier of English Rugby Union is a mixture of professional and semi-professional players, the 3rd tier is mainly semi-pro. Younger players from the first tier sides are routinely sent out on loan to second and third tier clubs to gain experience. This can work the other way as well — recently an injury crisis in a specialised position (tighthead prop) at my local top flight side led to a semi-pro player who works as a Air Force Falcons Armed Forces Bowl Champs 2023 shirt from a 3rd tier club being borrowed on loan. One minute he’s teaching kids, the next he’s running out infront of 15,000 supporters alongside international players being paid over $500,000 a year.
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